Prevalence of Hormone-Related Cancers (HRCs) at Two-Time Points in Rural Saskatchewan: The Saskatchewan Rural Health Study (SRHS)

J Occup Environ Med. 2021 Apr 1;63(4):e203-e214. doi: 10.1097/JOM.0000000000002161.

Abstract

Objective: This study aimed to determine the prevalence of hormone-related cancers (HRCs) among Saskatchewan rural dwellers and explore associated risk factors.

Methods: Data were analyzed from the Saskatchewan Rural Health Study (SRHS), which was a prospective cohort (2010 to 2014). Completed questionnaires were obtained from 4624 (2797) households, with information about 8261 (4867) individuals more than or equal to 18 years at baseline (follow-up). The crude prevalence of HRCs was calculated using appropriate formulae. Adjusted prevalence was calculated using logistic regression based on the generalized estimating equation (GEE).

Results: Crude prevalence of HRCs was 3.0% at the baseline. Variables significantly associated with HRCs were: exposure to radiation comprising ultraviolet radiation from sunlight as well as ionizing radiation (odds ratio [OR] 3.39; 95% confidence interval [CI]: 2.23, 4.84), previous history of cancer in sibling (OR = 1.51, 95% CI: 1.11, 2.07) and in father (OR = 1.37; 95% CI = 1.01, 1.86).

Conclusions: The study informs the Saskatchewan Health Region for health care resource allocation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Hormones
  • Humans
  • Neoplasms* / epidemiology
  • Prevalence
  • Prospective Studies
  • Rural Health*
  • Rural Population
  • Saskatchewan / epidemiology
  • Ultraviolet Rays

Substances

  • Hormones