Patient with Down syndrome and relapsed acute lymphoblastic leukemia with sustained remission despite only partial R3 chemotherapy

Zhongbo Hu; Kristen A VanHeyst; Jignesh Dalal; Lisa Hackney

doi:10.1002/ccr3.3678

Patient with Down syndrome and relapsed acute lymphoblastic leukemia with sustained remission despite only partial R3 chemotherapy

Clin Case Rep. 2021 Feb 12;9(3):1118-1122. doi: 10.1002/ccr3.3678. eCollection 2021 Mar.

Authors

Zhongbo Hu¹, Kristen A VanHeyst¹, Jignesh Dalal¹, Lisa Hackney¹

Affiliation

¹ Department of Pediatrics Division of Pediatric Hematology Oncology Rainbow Babies and Children's Hospital at University Hospitals Cleveland Medical Center Cleveland OH USA.

Abstract

DS-ALL has a higher rate of relapse and treatment-related mortality. The newer immunotherapies are potentially better options. Relapsed ALL with positive MRD has a poor prognosis. Transient long-term remission after ALL relapse due to partial chemotherapy combined severe infection is rare.

Keywords: ALL R3; Down syndrome; Relapsed acute lymphoblastic leukemia; remission.

Publication types

Case Reports

Grants and funding

K12 CA076917/CA/NCI NIH HHS/United States