Induction of the sphingosine-1-phosphate signaling pathway by TGF-β1 during Langerhans-type dendritic cell differentiation

Eur J Immunol. 2021 Jul;51(7):1854-1856. doi: 10.1002/eji.202049013. Epub 2021 Apr 19.

Abstract

Gene profiling revealed that the S1P signaling pathway is induced by TGF-β1 during LC commitment of monocytopoietic cells. Constitutive-active TGF-β1-S1P signaling seems to elevate the activation threshold of LCs and thereby prevent inappropriate and overshooting immune responses to microbial and physicochemical environmental signals. In turn, signals that lead to LC migration may disrupt this pathway via inhibiting S1P bioavailability.

Keywords: TGF-β1; dendritic cells; inflammation; langerhans cells; sphingosine-1-phosphate.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Differentiation / physiology*
  • Cell Movement / physiology
  • Cells, Cultured
  • Dendritic Cells / metabolism*
  • Humans
  • Langerhans Cells / metabolism*
  • Lysophospholipids / metabolism*
  • Signal Transduction / physiology*
  • Sphingosine / analogs & derivatives*
  • Sphingosine / metabolism
  • Transforming Growth Factor beta1 / metabolism*

Substances

  • Lysophospholipids
  • TGFB1 protein, human
  • Transforming Growth Factor beta1
  • sphingosine 1-phosphate
  • Sphingosine