Automated analysis of physiological time series is utilized for many clinical applications in medicine and life sciences. Long short-term memory (LSTM) is a deep recurrent neural network architecture used for classification of time-series data. Here time-frequency and time-space properties of time series are introduced as a robust tool for LSTM processing of long sequential data in physiology. Based on classification results obtained from two databases of sensor-induced physiological signals, the proposed approach has the potential for (1) achieving very high classification accuracy, (2) saving tremendous time for data learning, and (3) being cost-effective and user-comfortable for clinical trials by reducing multiple wearable sensors for data recording.