Whole-genome sequencing reveals progressive versus stable myeloma precursor conditions as two distinct entities

Nat Commun. 2021 Mar 25;12(1):1861. doi: 10.1038/s41467-021-22140-0.

Abstract

Multiple myeloma (MM) is consistently preceded by precursor conditions recognized clinically as monoclonal gammopathy of undetermined significance (MGUS) or smoldering myeloma (SMM). We interrogate the whole genome sequence (WGS) profile of 18 MGUS and compare them with those from 14 SMMs and 80 MMs. We show that cases with a non-progressing, clinically stable myeloma precursor condition (n = 15) are characterized by later initiation in the patient's life and by the absence of myeloma defining genomic events including: chromothripsis, templated insertions, mutations in driver genes, aneuploidy, and canonical APOBEC mutational activity. This data provides evidence that WGS can be used to recognize two biologically and clinically distinct myeloma precursor entities that are either progressive or stable.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA Copy Number Variations / genetics
  • Disease Progression
  • Genome, Human / genetics*
  • Humans
  • Monoclonal Gammopathy of Undetermined Significance / genetics*
  • Monoclonal Gammopathy of Undetermined Significance / pathology
  • Multiple Myeloma / genetics*
  • Multiple Myeloma / pathology
  • Polymorphism, Single Nucleotide / genetics
  • Risk Factors
  • Smoldering Multiple Myeloma / genetics*
  • Smoldering Multiple Myeloma / pathology
  • Whole Genome Sequencing