Thiopurine Use During Pregnancy Has Deleterious Effects on Offspring in Nudt15^R138C Knock-In Mice

Cell Mol Gastroenterol Hepatol. 2021;12(1):335-337. doi: 10.1016/j.jcmgh.2021.03.006. Epub 2021 Mar 23.

Authors

T Imai¹, M Kawahara², G Tatsumi¹, N Yamashita¹, A Nishishita-Asai¹, O Inatomi¹, A Masamune³, Y Kakuta³, A Andoh¹

Affiliations

¹ Division of Gastroenterology and Hematology, Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan.
² Division of Gastroenterology and Hematology, Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan. Electronic address: mkawahar@belle.shiga-med.ac.jp.
³ Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.

No abstract available

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Female
Genotype
Immunosuppressive Agents / toxicity*
Mice
Pregnancy
Purines / toxicity*
Pyrophosphatases / antagonists & inhibitors*
Pyrophosphatases / genetics
Pyrophosphatases / metabolism

Substances

Immunosuppressive Agents
Purines
Pyrophosphatases
Nudt15 protein, mouse