Recent Progress of DNA Nanostructures on Amphiphilic Membranes

Jiafang Piao; Wei Yuan; Yuanchen Dong

doi:10.1002/mabi.202000440

Recent Progress of DNA Nanostructures on Amphiphilic Membranes

Macromol Biosci. 2021 May;21(5):e2000440. doi: 10.1002/mabi.202000440. Epub 2021 Mar 24.

Authors

Jiafang Piao^{1

2}, Wei Yuan^{1

2}, Yuanchen Dong^{1

2}

Affiliations

¹ CAS Key Laboratory of Colloid, Interface and Chemical Thermodynamics, Chinese Academy of Sciences, Institute of Chemistry, Beijing, 100190, China.
² Beijing National Laboratory for Molecular Sciences, Chinese Academy of Sciences, Institute of Chemistry, Beijing, 100190, China.

PMID: 33759366
DOI: 10.1002/mabi.202000440

Abstract

Employing DNA nanostructures mimicking membrane proteins on artificial amphiphilic membranes have been widely developed to understand the structures and functions of the natural membrane systems. In this review, the recent developments in artificial systems constructed by amphiphilic membranes and DNA nanostructures are summarized. First, the preparations and properties of the amphipathic bilayer models are introduced. Second, the interactions are discussed between the membrane and the DNA nanostructures, as well as their coassembly behaviors. Next, the alternative systems related to membrane protein-mediated signal transmission, selective distribution, transmembrane channels, and membrane fusion are also introduced. Moreover, the constructions of membrane skeleton protein-mimicking DNA nanostructures are also highlighted.

Keywords: DNA nanostructures; amphiphilic membranes; membrane proteins; self-assembly.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

DNA / chemistry*
Membranes, Artificial*
Nanostructures*

Substances

Membranes, Artificial
DNA