Identification of bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors from a library of natural products

Signal Transduct Target Ther. 2021 Mar 23;6(1):131. doi: 10.1038/s41392-021-00531-5.

Chang-Long He^#¹, Lu-Yi Huang^#¹, Kai Wang^#¹, Chen-Jian Gu², Jie Hu¹, Gui-Ji Zhang¹, Wei Xu², You-Hua Xie^{3

4}, Ni Tang⁵, Ai-Long Huang⁶

¹ Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
² Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
³ Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China. yhxie@fudan.edu.cn.
⁴ Children's Hospital, Fudan University, Shanghai, China. yhxie@fudan.edu.cn.
⁵ Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China. nitang@cqmu.edu.cn.
⁶ Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China. ahuang@cqmu.edu.cn.

^# Contributed equally.

No abstract available

Publication types