Serotoninergic system targeting in multiple sclerosis: the prospective for pathogenetic therapy

Mikhail Melnikov; Anastasiya Sviridova; Vladimir Rogovskii; Alexander Oleskin; Marina Boziki; Christos Bakirtzis; Evangelia Kesidou; Nikolaos Grigoriadis; Alexey Boykо

doi:10.1016/j.msard.2021.102888

Serotoninergic system targeting in multiple sclerosis: the prospective for pathogenetic therapy

Mult Scler Relat Disord. 2021 Jun:51:102888. doi: 10.1016/j.msard.2021.102888. Epub 2021 Mar 10.

Authors

Mikhail Melnikov¹, Anastasiya Sviridova², Vladimir Rogovskii², Alexander Oleskin³, Marina Boziki⁴, Christos Bakirtzis⁴, Evangelia Kesidou⁴, Nikolaos Grigoriadis⁴, Alexey Boykо²

Affiliations

¹ Department of Neuroimmunology, Federal Center of Brain research and Neurotechnology of the Federal Medical-Biological Agency of Russia; Department of Neurology, Neurosurgery and Medical Genetics and Department of Molecular Pharmacology and Radiobiology, Pirogov Russian National Research Medical University, Moscow, Russia; Laboratory of Clinical Immunology, National Research Center Institute of Immunology of the Federal Medical-Biological Agency of Russia, Moscow, Russia. Electronic address: medikms@yandex.ru.
² Department of Neuroimmunology, Federal Center of Brain research and Neurotechnology of the Federal Medical-Biological Agency of Russia; Department of Neurology, Neurosurgery and Medical Genetics and Department of Molecular Pharmacology and Radiobiology, Pirogov Russian National Research Medical University, Moscow, Russia.
³ General Ecology and Hydrobiology Department, School of Biology, Moscow State University, Moscow, Russia.
⁴ 2nd Neurological University Department, Aristotle University of Thessaloniki, AHEPA General Hospital, Thessaloniki, Greece.

PMID: 33756440
DOI: 10.1016/j.msard.2021.102888

Abstract

Serotonin (5-hydroxytryptamine) (5-HT) is a neurotransmitter, which mediates neuropsychological functions of the central nervous system (CNS). Recent studies have shown the modulatory effect of 5-HT on gut microbiota functions, which play an essential role in developing CNS inflammatory diseases. Finally, 5-HT is a direct mediator of neuroimmune interaction. The article reviews the literature data on the role of 5-HT in the regulation of neuroinflammation in multiple sclerosis (MS). The influence of 5-HT and selective serotonin reuptake inhibitors (SSRIs) on experimental autoimmune encephalomyelitis (EAE) and MS pathogenesis, as well as the therapeutic potential of serotoninergic drugs as a pathogenetic therapy of MS, are discussed.

Keywords: 5-HT; SSRIs; Th17-cells, multiple sclerosis; gut-brain axis; neuroimmune interaction.

Publication types

Review

MeSH terms

Animals
Central Nervous System
Encephalomyelitis, Autoimmune, Experimental*
Gastrointestinal Microbiome*
Humans
Multiple Sclerosis* / drug therapy
Prospective Studies