Molecular characterization and analysis of the association of growth hormone 1 gene with growth traits in Chinese indigenous yak (Bos grunniens)

Linsheng Gui; Sayed Haidar Abbas Raza; Yonggang Sun; Ahmed Sabek; Sayed Qaisar Abbas; Mujahid Ali Shah; Rajwali Khan; Sameh A Abdelnour

doi:10.1007/s11250-021-02671-w

Molecular characterization and analysis of the association of growth hormone 1 gene with growth traits in Chinese indigenous yak (Bos grunniens)

Trop Anim Health Prod. 2021 Mar 22;53(2):221. doi: 10.1007/s11250-021-02671-w.

Authors

Linsheng Gui¹, Sayed Haidar Abbas Raza², Yonggang Sun³, Ahmed Sabek^{4

5}, Sayed Qaisar Abbas⁶, Mujahid Ali Shah⁷, Rajwali Khan⁸, Sameh A Abdelnour⁹

Affiliations

¹ College of Agriculture and Animal Husbandry, Qinghai University, Xining, Qinghai Province, 810016, People's Republic of China.
² State Key Laboratory of Animal Genetics Breeding & Reproduction, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, People's Republic of China. haiderraza110@nwafu.edu.cn.
³ Qinghai Academy of Animal Science and Veterinary Medicine, Qinghai University, Xining, Qinghai Province, 810016, People's Republic of China.
⁴ Department of Veterinary Hygiene and Management, Faculty of Veterinary Medicine, Benha University, Moshtohor, Kalyobiya, 13736, Egypt.
⁵ Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction Ministry of Education, Huazhong Agricultural University, Wuhan, 430070, Hubei, People's Republic of China.
⁶ Department of Management Sciences, National University of Modern Languages, Islamabad, Pakistan.
⁷ Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, University of South Bohemia in Ceske Budejovice, Zatisi 728/II, 389 25, Vodnany, Czech Republic.
⁸ Department of Livestock Management, Breeding and Genetics, The University of Agriculture, Peshawar, Pakistan.
⁹ Department of Animal Production, Faculty of Agriculture, Zagazig University, Zagazig, 44511, Egypt.

PMID: 33754201
DOI: 10.1007/s11250-021-02671-w

Abstract

This study aimed to investigate the effects of polymorphisms in growth hormone 1 (GH1) gene on the growth traits in Chinese indigenous yak. Using the polymerase chain reaction-restriction fragment length polymorphism (PCR-PFLP) approach, one novel single-nucleotide polymorphism (SNP), termed as g.1721G>A, was identified in the exon 4 of GH1 gene in 423 individuals of yak population. Based on the chi-square (χ²) test, the frequencies of g.1721G>A alleles agreed with Hardy-Weinberg equilibrium (HWE) (P < 0.05). A significant association was observed between this SNP and several growth traits (P < 0.01 or P < 0.05), in which the genotype GG exhibited the best values. The present study suggested that the identified SNP was a useful genetic marker for the improvement of growth traits in Chinese indigenous yak.

Keywords: Growth hormone 1 gene; Growth traits; Molecular characterization; Single-nucleotide polymorphism.

MeSH terms

Alleles
Animals
Cattle / genetics
China
Gene Frequency
Genotype
Growth Hormone
Phenotype
Polymorphism, Single Nucleotide*

Substances

Growth Hormone

Grants and funding

31960649/The research was supported by National Natural Science Foundation of China (31960649).