IgLON 5 Antibody Syndrome: Isolated Case of a Patient With Indolent Disease Progression and Unusual MRI Findings

Sihyeong Park; Jonathan Doan; Irfan Sheikh; Ajaz A Sheikh

doi:10.7759/cureus.13386

IgLON 5 Antibody Syndrome: Isolated Case of a Patient With Indolent Disease Progression and Unusual MRI Findings

Cureus. 2021 Feb 17;13(2):e13386. doi: 10.7759/cureus.13386.

Authors

Sihyeong Park¹, Jonathan Doan¹, Irfan Sheikh¹, Ajaz A Sheikh¹

Affiliation

¹ Neurology, University of Toledo Medical Center, Toledo, USA.

Abstract

IgLON-5 antibody syndrome has a myriad of clinical presentations, including gait instability, movement disorders, abnormal eye movements, bulbar symptoms, sleep disorders, neuropsychiatric symptoms, dysautonomia, and peripheral neuropathy. Abnormal magnetic resonance imaging (MRI) findings have also been reported such as leukoariotic changes and cerebral and cerebellar atrophy. We present a case of IgLON-5 antibody syndrome with a unique MRI finding of persistent leptomeningeal enhancement. A close follow-up would be warranted as the progression of the disease may be indolent.

Keywords: iglon-5; leptomeningeal enhancement.

Publication types

Case Reports