Dose-response meta-analysis of arsenic exposure in drinking water and hypertension

Afsaneh Amiri; Yaser Mokhayeri; Rasool Mohammadi; Mohammad Amin Karami; Mansour Ghaderpoori; Bahram Kamarehie; Ali Jafari

doi:10.1016/j.heliyon.2021.e06409

Dose-response meta-analysis of arsenic exposure in drinking water and hypertension

Heliyon. 2021 Mar 12;7(3):e06409. doi: 10.1016/j.heliyon.2021.e06409. eCollection 2021 Mar.

Authors

Afsaneh Amiri¹, Yaser Mokhayeri², Rasool Mohammadi^{3

4}, Mohammad Amin Karami¹, Mansour Ghaderpoori¹, Bahram Kamarehie¹, Ali Jafari¹

Affiliations

¹ Department of Environmental Health Engineering, Environmental Health Research Center, School of Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran.
² Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khorramabad, Iran.
³ Assistant Professor of Epidemiology, Department of Biostatistics and Epidemiology, School of Public Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran.
⁴ Nutritional Health Research Center, Health and Nutritional Department, Lorestan University of Medical Sciences, Khorramabad, Iran.

Abstract

Background: Based on the cross-sectional and cohort studies, exposure to As via drinking water can cause hypertension.

Methods: We searched PubMed, ISI WOS, and Scopus for relevant studies up to 1 January 2018 using related keywords. The meta-analysis was done on 10 studies (n = 28255) that report Odds Ratio for hypertension. The extracted ORs between As concentration and hypertension were pooled using random effect models. Study heterogeneity was analyzed using I ².

Results: The estimated adjusted OR for association between As and hypertension was 1.44 (95% CI: 1.12, 1.84) with I ² = 71%. Dose-Response analysis showed a linear relationship between As and hypertension (OR = 1.0008 95% CI: 1.0003, 1.001). In general, by increase of each unit in arsenic concentration, odds of the hypertension would increase as 0.08%.

Conclusion: There was a significant relationship between As exposure and hypertension.

Keywords: Arsenic; Chronic exposure; Drinking water; Health risk; Meta-analysis.

Publication types

Review