[Vulvar intraepithelial neoplasias]

Abstract

Vulvar squamous cell carcinoma arises from precursor lesions: vulvar intraepithelial neoplasias (VIN). Most of them are caused by the human papillomavirus (HPV), and the precursor lesion for this group is VIN usual type/high grade squamous intraepithelial lesion (uVIN/HSIL) of variable clinical presentation and having a light invasive potential. Some VIN are HPV-independent and arise in older women against the background of chronic dermatoses, mostly lichen sclerosus. Their histological diagnosis is more subtle. They have a higher invasive potential. A third precursor, leading to well-differentiated, or even verrucous, carcinomas, is still ill-defined to this day. We detail these lesions' clinics, histology, and biomarkers (immunohistochemical and molecular).

Keywords: Carcinome épidermoïde; Differentiated type VIN HPV; HPV; HSIL; High grade squamous intraepithelial lesion; Néoplasie intraépithéliale; P16; VIN; VIN classic type; VIN differenciée; VIN indifférencié; VIN type classique; Vulva squamous cell carcinoma; Vulve; intraepithélial neoplasia.