Constantin von Economo (1876-1931) had a long-standing interest in the cellular structure of the human cerebral cortex. In the present article I highlight a historical paper that von Economo published in 1930 on the cytoarchitectonics of the Rolandic operculum, an English translation of which I provide as supplementary material. I further discuss some morphofunctional aspects of the human opercular cortex from a modern perspective, as well as the clinical relevance to language dysfunctions, the operculum syndrome, and epilepsy.
Keywords: Cerebral cortex; Constantin von Economo (1876–1931); Cytoarchitectonics; Frontoparietal operculum; History of neuroscience.