The role of LTBPs in TGF beta signaling

Daniel Rifkin; Nalani Sachan; Karan Singh; Elyse Sauber; George Tellides; Francesco Ramirez

doi:10.1002/dvdy.331

The role of LTBPs in TGF beta signaling

Dev Dyn. 2022 Jan;251(1):95-104. doi: 10.1002/dvdy.331. Epub 2021 Mar 25.

Authors

Daniel Rifkin¹, Nalani Sachan¹, Karan Singh¹, Elyse Sauber¹, George Tellides², Francesco Ramirez³

Affiliations

¹ Department of Cell Biology, NYU Grossman School of Medicine, New York, New York, USA.
² Department of Surgery, Yale School of Medicine, New Haven, Connecticut, USA.
³ Department of Pharmacological Sciences, Icahn School of Medicine at Mt Sinai, New York, New York, USA.

PMID: 33742701
DOI: 10.1002/dvdy.331

Abstract

The purpose of this review is to discuss the transforming growth factor beta (TGFB) binding proteins (LTBP) with respect to their participation in the activity of TGFB. We first describe pertinent aspects of the biology and cell function of the LTBPs. We then summarize the physiological consequences of LTBP loss in humans and mice. Finally, we consider a number of outstanding questions relating to LTBP function.

Keywords: LTBP; TGF beta; cell signaling; mouse mutants.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
Humans
Latent TGF-beta Binding Proteins* / genetics
Latent TGF-beta Binding Proteins* / metabolism
Mice
Protein Binding
Signal Transduction
Transforming Growth Factor beta / metabolism

Substances

Latent TGF-beta Binding Proteins
Transforming Growth Factor beta

Abstract

Publication types

MeSH terms

Substances

Grants and funding