Antivirals with common targets against highly pathogenic viruses

Lu Lu; Shan Su; Haitao Yang; Shibo Jiang

doi:10.1016/j.cell.2021.02.013

Antivirals with common targets against highly pathogenic viruses

Cell. 2021 Mar 18;184(6):1604-1620. doi: 10.1016/j.cell.2021.02.013.

Authors

Lu Lu¹, Shan Su¹, Haitao Yang², Shibo Jiang³

Affiliations

¹ Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200032, China.
² Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, Shanghai Tech University, Shanghai 201210, China. Electronic address: yanght@shanghaitech.edu.cn.
³ Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200032, China. Electronic address: shibojiang@fudan.edu.cn.

PMID: 33740455
DOI: 10.1016/j.cell.2021.02.013

Abstract

Historically, emerging viruses appear constantly and have cost millions of human lives. Currently, climate change and intense globalization have created favorable conditions for viral transmission. Therefore, effective antivirals, especially those targeting the conserved protein in multiple unrelated viruses, such as the compounds targeting RNA-dependent RNA polymerase, are urgently needed to combat more emerging and re-emerging viruses in the future. Here we reviewed the development of antivirals with common targets, including those against the same protein across viruses, or the same viral function, to provide clues for development of antivirals for future epidemics.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antiviral Agents / pharmacology
Antiviral Agents / therapeutic use*
Communicable Diseases, Emerging / drug therapy*
Communicable Diseases, Emerging / epidemiology*
Communicable Diseases, Emerging / virology
Humans
Molecular Targeted Therapy / methods*
Pandemics*
RNA-Dependent RNA Polymerase / antagonists & inhibitors
Viral Envelope Proteins / antagonists & inhibitors
Virus Diseases / drug therapy*
Virus Diseases / epidemiology*
Virus Diseases / virology
Virus Internalization / drug effects
Viruses / enzymology*

Substances

Antiviral Agents
Viral Envelope Proteins
RNA-Dependent RNA Polymerase