More reliable breast cancer risk assessment for every woman

Cancer Cell. 2021 Apr 12;39(4):457-459. doi: 10.1016/j.ccell.2021.02.018. Epub 2021 Mar 18.

Abstract

Using large, unbiased cohorts, two studies in The New England Journal of Medicine assessed the associations between germline variants in putative cancer susceptibility genes and the risk of breast cancer. They consistently identified a small set of genes as being the most informative for risk prediction, helping select high-risk women in the general population, and developing effective cancer prevention strategies.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Breast Neoplasms / genetics
  • Breast Neoplasms / therapy*
  • Case-Control Studies
  • Clinical Trials as Topic*
  • Female
  • Genetic Predisposition to Disease / genetics*
  • Germ-Line Mutation
  • Humans
  • Risk Assessment*