YTHDC1 gene polymorphisms and Wilms tumor susceptibility in Chinese children: A five-center case-control study

Ao Lin; Rui-Xi Hua; Mingming Zhou; Wen Fu; Jiao Zhang; Haixia Zhou; Suhong Li; Jiwen Cheng; Jinhong Zhu; Huimin Xia; Guochang Liu; Jing He

doi:10.1016/j.gene.2021.145571

YTHDC1 gene polymorphisms and Wilms tumor susceptibility in Chinese children: A five-center case-control study

Gene. 2021 May 30:783:145571. doi: 10.1016/j.gene.2021.145571. Epub 2021 Mar 16.

Authors

Ao Lin¹, Rui-Xi Hua¹, Mingming Zhou², Wen Fu¹, Jiao Zhang³, Haixia Zhou⁴, Suhong Li⁵, Jiwen Cheng⁶, Jinhong Zhu⁷, Huimin Xia¹, Guochang Liu¹, Jing He⁸

Affiliations

¹ Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China.
² Department of Clinical Laboratory, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, China.
³ Department of Pediatric Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China.
⁴ Department of Hematology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang, China.
⁵ Department of Pathology, Children Hospital and Women Health Center of Shanxi, Taiyuan 030013, Shannxi, China.
⁶ Department of Pediatric Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi, China.
⁷ Department of Clinical Laboratory, Biobank, Harbin Medical University Cancer Hospital, Harbin 150040, Heilongjiang, China.
⁸ Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China. Electronic address: hejing198374@gmail.com.

PMID: 33737126
DOI: 10.1016/j.gene.2021.145571

Abstract

Wilms tumor is a common pediatric tumor with abundant genetic drivers. YTHDC1 is an important reader of the N⁶-methyladenosine modification that widely regulates eukaryotic transcripts. YTHDC1 has been associated with the occurrence and development of some tumors. However, this is the first study on YTHDC1 gene polymorphisms and Wilms tumor susceptibility. In brief, we conducted a five-center case-control study to explore the associations between YTHDC1 polymorphisms (rs2293596 T > C, rs2293595 T > C, and rs3813832 T > C) and Wilms tumor susceptibility in Chinese children. A total of 404 cases and 1198 controls were successfully genotyped using TaqMan real-time PCR. Odds ratios (ORs) and 95% confidence intervals (CIs) were used as the evaluation indicators. We found that children with the 2-3 risk genotypes were more likely to develop Wilms tumor than those with the 0-1 risk genotypes (adjusted OR = 1.28, 95% CI = 1.01-1.62, P = 0.042). However, no other statistically significant results were found in this research study. The combined effect of YTHDC1 polymorphisms significantly increases Wilms tumor susceptibility. Our results need to be verified in different populations after increasing the sample size and controlling for confounding factors.

Keywords: M(6)A; Polymorphism; Susceptibility; Wilms tumor; YTHDC1.

MeSH terms

Asian People / genetics*
Case-Control Studies
Child, Preschool
Female
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Humans
Infant
Male
Nerve Tissue Proteins / genetics*
Polymorphism, Genetic
RNA Splicing Factors / genetics*
Wilms Tumor / genetics*

Substances

Nerve Tissue Proteins
RNA Splicing Factors
YTHDC1 protein, human