MicroRNAs on the move: microRNAs in astrocyte-derived ApoE particles regulate neuronal function

Hande Karahan; Luke C Dabin; Mason D Tate; Jungsu Kim

doi:10.1016/j.neuron.2021.02.021

MicroRNAs on the move: microRNAs in astrocyte-derived ApoE particles regulate neuronal function

Neuron. 2021 Mar 17;109(6):907-909. doi: 10.1016/j.neuron.2021.02.021.

Authors

Hande Karahan¹, Luke C Dabin¹, Mason D Tate², Jungsu Kim³

Affiliations

¹ Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
² Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA; Medical Neuroscience Graduate Program, Indiana University School of Medicine, Indianapolis, IN, USA.
³ Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA; Medical Neuroscience Graduate Program, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: jk123@iu.edu.

PMID: 33735610
DOI: 10.1016/j.neuron.2021.02.021

Abstract

In this issue of Neuron, Li et al. (2021) demonstrate that ApoE lipoprotein particles shuttle miRNAs from astrocytes to neurons, leading to inhibition of cholesterol biosynthesis and an increase in histone acetylation in neurons.

Publication types

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MeSH terms

Acetylation
Apolipoproteins E / genetics
Astrocytes* / metabolism
Cells, Cultured
Cholesterol
Histones
MicroRNAs* / genetics
MicroRNAs* / metabolism
Neurons / metabolism

Substances

Apolipoproteins E
Histones
MicroRNAs
Cholesterol