Profile of specific antibodies to the SARS-CoV-2

J Med Microbiol. 2021 Mar;70(3):001335. doi: 10.1099/jmm.0.001335. Epub 2021 Mar 18.

Abstract

In this work, we studied the profile of IgM and IgG antibody responses to SARS-CoV-2 in 32 patients with COVID-19 from day 1 to day 24. IgM remained measurable for a much shorter period than IgG, suggesting that IgG antibody may represent the primary immune response.

Keywords: SARS-CoV-2; Spike RBD protein; antibodies.

MeSH terms

  • Adult
  • Aged
  • Antibodies, Viral / blood*
  • COVID-19 / diagnosis
  • COVID-19 / immunology*
  • Coronavirus Nucleocapsid Proteins / immunology
  • Female
  • Humans
  • Immunoglobulin G / blood
  • Immunoglobulin M / blood
  • Kinetics
  • Male
  • Middle Aged
  • Phosphoproteins / immunology
  • RNA, Viral / analysis
  • SARS-CoV-2 / genetics
  • SARS-CoV-2 / immunology*
  • SARS-CoV-2 / isolation & purification
  • Spike Glycoprotein, Coronavirus / immunology

Substances

  • Antibodies, Viral
  • Coronavirus Nucleocapsid Proteins
  • Immunoglobulin G
  • Immunoglobulin M
  • Phosphoproteins
  • RNA, Viral
  • Spike Glycoprotein, Coronavirus
  • nucleocapsid phosphoprotein, SARS-CoV-2
  • spike protein, SARS-CoV-2