VEGF-Induced Endothelial Podosomes via ROCK2-Dependent Thrombomodulin Expression Initiate Sprouting Angiogenesis

Arterioscler Thromb Vasc Biol. 2021 May 5;41(5):1657-1671. doi: 10.1161/ATVBAHA.121.315931. Epub 2021 Mar 18.

Cheng-Hsiang Kuo^{1

2}, Yi-Hsun Huang^{3

4}, Po-Ku Chen^{1

5}, Gang-Hui Lee², Ming-Jer Tang², Edward M Conway⁶, Guey-Yueh Shi¹, Hua-Lin Wu^{1

2}

¹ Department of Biochemistry and Molecular Biology, National Cheng Kung University, Tainan, Taiwan (C.-H.K., P.-K.C., G.-Y.S., H.-L.W.)
² College of Medicine and International Center for Wound Repair and Regeneration, National Cheng Kung University, Tainan, Taiwan (C.-H.K., G.-H.L., M.-J.T., H.-L.W.)
³ Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan (Y.-H.H.)
⁴ Department of Ophthalmology, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan (Y.-H.H.)
⁵ Now with Translational Medicine Laboratory, Rheumatology and Immunology Center, China Medical University Hospital, Taichung, Taiwan (P.-K. C.)
⁶ Department of Medicine, Centre for Blood Research, Life Sciences Institute, University of British Columbia, Vancouver, Canada (E.M.C.).

Abstract

[Figure: see text].

Keywords: extracellular matrix; lectin; morphogenesis; podosomes; thrombomodulin.