Effects of post-exercise sodium bicarbonate ingestion on acid-base balance recovery and time-to-exhaustion running performance: a randomised crossover trial in recreational athletes

Appl Physiol Nutr Metab. 2021 Sep;46(9):1111-1118. doi: 10.1139/apnm-2020-1120. Epub 2021 Mar 17.

Abstract

This study investigated the effect of post-exercise sodium bicarbonate (NaHCO3) ingestion on acid-base balance recovery and time-to-exhaustion (TTE) running performance. Eleven male runners (stature, 1.80 ± 0.05 m; body mass, 74.4 ± 6.5 kg; maximal oxygen consumption, 51.7 ± 5.4 mL·kg-1·min-1) participated in this randomised, single-blind, counterbalanced and crossover design study. Maximal running velocity (v-O2max) was identified from a graded exercise test. During experimental trials, participants repeated 100% v-O2max TTE protocols (TTE1, TTE2) separated by 40 min following the ingestion of either 0.3 g·kg-1 body mass NaHCO3 (SB) or 0.03 g·kg-1 body mass sodium chloride (PLA) at the start of TTE1 recovery. Acid-base balance (blood pH and bicarbonate, HCO3-) data were studied at baseline, post-TTE1, after 35 min recovery and post-TTE2. Blood pH and HCO3- concentration were unchanged at 35 min recovery (p > 0.05), but HCO3- concentration was elevated post-TTE2 for SB vs. PLA (+2.6 mmol·L-1; p = 0.005; g = 0.99). No significant differences were observed for TTE2 performance (p > 0.05), although a moderate effect size was present for SB vs. PLA (+14.3 s; g = 0.56). Post-exercise NaHCO3 ingestion is not an effective strategy for accelerating the restoration of acid-base balance or improving subsequent TTE performance when limited recovery is available. Novelty: Post-exercise sodium bicarbonate ingestion did not accelerate the restoration of blood pH or bicarbonate after 35 min. Performance enhancing effects of sodium bicarbonate ingestion may display a high degree of inter-individual variation. Small-to-moderate changes in performance were likely due to greater up-regulation of glycolytic activation during exercise.

Keywords: activation glycolytique; aide ergogène; alcalose; alkalosis; buffering; capacité d’exercice; ergogenic aid; exercise capacity; glycolytic activation; nutrition; tamponnage.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Acid-Base Equilibrium / drug effects*
  • Athletic Performance / physiology
  • Beverages*
  • Buffers
  • Cross-Over Studies
  • Glycolysis
  • Humans
  • Hydrogen-Ion Concentration
  • Male
  • Oxygen Consumption
  • Perception / physiology
  • Physical Endurance / physiology*
  • Physical Exertion / physiology
  • Running / physiology*
  • Single-Blind Method
  • Sodium Bicarbonate / administration & dosage*
  • Sodium Bicarbonate / blood

Substances

  • Buffers
  • Sodium Bicarbonate