A novel quantitative analysis method for idiopathic epiretinal membrane

PLoS One. 2021 Mar 17;16(3):e0247192. doi: 10.1371/journal.pone.0247192. eCollection 2021.

Abstract

Purpose: To introduce a novel method to quantitively analyse in three dimensions traction forces in a vast area of the ocular posterior pole.

Methods: Retrospective analysis of 14 eyes who underwent peeling surgery for idiopathic, symptomatic and progressive epiretinal membrane. The technique measures the shift in position of vascular crossings after surgery from a fixed point, which is the retinal pigmented epithelium. This shift is defined as the relaxation index (RI) and represents a measure of the postoperative movement of the retina due to released traction after surgery.

Results: Best-corrected visual acuity was significantly better than baseline at all follow ups while the RI had its maximum value at baseline. Moreover, we found a significant correlation between best-corrected visual acuity at 6 months and RI at baseline.

Conclusion: While all previous published methods focused on bi-dimensional changes observed in a small region, this study introduces a three-dimensional assessment of tractional forces. Future integration of RI into built-in processing software will allow systematic three-dimensional measurement of intraretinal traction.

MeSH terms

  • Aged
  • Epiretinal Membrane / surgery
  • Evaluation Studies as Topic
  • Female
  • Humans
  • Male
  • Retina / surgery
  • Retinal Pigment Epithelium / metabolism
  • Retinal Pigment Epithelium / surgery
  • Retrospective Studies
  • Tomography, Optical Coherence / methods*
  • Visual Acuity / physiology
  • Vitrectomy / methods*

Grants and funding

Unfunded studies The author(s) received no specific funding for this work.