Preface to the Special Issue "Presynaptic Dysfunction and Disease"

Karen J Smillie; Michael A Cousin; Sarah L Gordon

doi:10.1111/jnc.15319

Preface to the Special Issue "Presynaptic Dysfunction and Disease"

J Neurochem. 2021 Apr;157(2):102-106. doi: 10.1111/jnc.15319. Epub 2021 Mar 17.

Authors

Karen J Smillie^{1

2}, Michael A Cousin^{1

2

3}, Sarah L Gordon⁴

Affiliations

¹ Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, Scotland.
² Muir Maxwell Epilepsy Centre, University of Edinburgh, Edinburgh, Scotland.
³ Simons Initiative for the Developing Brain, University of Edinburgh, Edinburgh, Scotland.
⁴ The Florey Institute of Neuroscience and Mental Health, Melbourne Dementia Research Centre, The University of Melbourne, Melbourne, Vic., Australia.

PMID: 33728654
DOI: 10.1111/jnc.15319

Abstract

The synapse is formed between a presynapse (which releases neurotransmitter) and the postsynapse (which transduces this chemical signal). Over the past decade, presynaptic dysfunction has emerged as a key mediator of a series of neurodevelopmental and neurodegenerative disorders. This special issue will highlight some of the important presynaptic molecules and mechanisms that are disrupted in these conditions and reveal potential routes for therapy.

Keywords: JNeurochem Special issue “Presynaptic Dysfunction and Disease”; calcium; neurodegeneration; neurodevelopmental disorder; neurotransmitter; presynapse; synaptic vesicle.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Humans
Neurodegenerative Diseases* / drug therapy
Neurodegenerative Diseases* / metabolism
Neurotransmitter Agents / metabolism*
Presynaptic Terminals / metabolism*
Synapses / metabolism*
Synaptic Vesicles / metabolism*

Substances

Neurotransmitter Agents

Abstract

Publication types

MeSH terms

Substances

Grants and funding