Deficiency of ARHGAP21 alters megakaryocytic cell lineage responses and enhances platelet hemostatic function

Biochim Biophys Acta Mol Cell Res. 2021 May;1868(6):119012. doi: 10.1016/j.bbamcr.2021.119012. Epub 2021 Mar 13.
No abstract available

Keywords: CDC42; Cytoskeleton; Megakaryocytes; Platelets; RHOA; Rho GTPase; RhoGAP.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Platelets / drug effects
  • Blood Platelets / physiology*
  • Cell Differentiation
  • Cell Line
  • Cell Lineage
  • Cells, Cultured
  • GTPase-Activating Proteins / genetics*
  • GTPase-Activating Proteins / metabolism
  • Gene Silencing
  • Humans
  • Megakaryocytes / cytology*
  • Megakaryocytes / drug effects
  • Megakaryocytes / metabolism
  • Mice
  • P-Selectin / pharmacology
  • Platelet Aggregation / drug effects
  • Primary Cell Culture
  • Thrombin / pharmacology
  • Up-Regulation*

Substances

  • ARHGAP21 protein, human
  • Arhgap21 protein, mouse
  • GTPase-Activating Proteins
  • P-Selectin
  • Thrombin