A trace gas detection technique of quartz-enhanced photoacoustic-photothermal spectroscopy (QEPA-PTS) is demonstrated. Different from quartz-enhanced photoacoustic spectroscopy (QEPAS) or quartz-enhanced photothermal spectroscopy (QEPTS), which detected only one single kind of signal, QEPA-PTS was realized by adding the photoacoustic and photothermal signals generated from two quartz tuning forks (QTFs), respectively. Water vapor (H2O) with a volume concentration of 1.01% was selected as the analyte gas to investigate the QEPA-PTS sensor performance. Compared to QEPAS and QEPTS, an enhanced signal level was achieved for this QEPA-PTS system. Further improvement of such a technique was proposed.