Ex vivo dual perfusion of an isolated cotyledon of human placenta: History and future challenges

Henning Schneider; Paul Brownbill; Christiane Albrecht

doi:10.1016/j.placenta.2021.02.017

Ex vivo dual perfusion of an isolated cotyledon of human placenta: History and future challenges

Placenta. 2021 Apr:107:8-12. doi: 10.1016/j.placenta.2021.02.017. Epub 2021 Mar 2.

Authors

Henning Schneider¹, Paul Brownbill², Christiane Albrecht³

Affiliations

¹ Department of Obstetrics and Gynecology, University Hospital, University of Bern, Bern, Switzerland. Electronic address: henning.schneider@hispeed.ch.
² Maternal and Fetal Health Research Centre, Division of Developmental Biology & Medicine, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, UK; St. Mary's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, M13 9WL, UK.
³ Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland; Swiss National Centre of Competence in Research (NCCR) TransCure, University of Bern, Switzerland.

PMID: 33725568
DOI: 10.1016/j.placenta.2021.02.017

Abstract

This is an introductory chapter for the Special Issue: Ex vivo dual perfusion of an isolated cotyledon of the human placenta. It covers the early stages of development of this technique in the laboratory of Professor Maurice Panigel. It was successfully further developed by Henning Schneider during his stay in Paris as a research assistant. Together with Professor Joseph Dancis in New York they managed to overcome initial problems of acceptance. Its value was finally confirmed by studies performed by several groups in different parts of the world and it became a valuable additional tool for research on the human placenta.

Keywords: Dual ex vivo perfusion; Human placenta.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Female
Humans
Perfusion*
Placenta*
Pregnancy