Impact of PPM1D mutations in patients with myelodysplastic syndrome and deletion of chromosome 5q

Am J Hematol. 2021 Jun 1;96(6):E207-E210. doi: 10.1002/ajh.26162. Epub 2021 Apr 7.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abnormal Karyotype
  • Adult
  • Aged
  • Aged, 80 and over
  • Alleles
  • Anemia, Macrocytic / genetics*
  • Chromosome Deletion
  • Chromosomes, Human, Pair 5 / genetics
  • Clonal Evolution
  • Disease Progression
  • Drug Resistance, Neoplasm / genetics
  • Female
  • Genes, p53
  • Humans
  • Lenalidomide / pharmacology
  • Lenalidomide / therapeutic use
  • Male
  • Middle Aged
  • Mutation*
  • Myelodysplastic Syndromes / drug therapy
  • Myelodysplastic Syndromes / genetics*
  • Protein Phosphatase 2C / genetics*
  • Protein Phosphatase 2C / physiology
  • Retrospective Studies

Substances

  • PPM1D protein, human
  • Protein Phosphatase 2C
  • Lenalidomide

Supplementary concepts

  • Chromosome 5q Deletion Syndrome