Neural correlates of emotional processing in psychosis risk and onset - A systematic review and meta-analysis of fMRI studies

P B Lukow; A Kiemes; M J Kempton; F E Turkheimer; P McGuire; G Modinos

doi:10.1016/j.neubiorev.2021.03.010

Neural correlates of emotional processing in psychosis risk and onset - A systematic review and meta-analysis of fMRI studies

Neurosci Biobehav Rev. 2021 Sep:128:780-788. doi: 10.1016/j.neubiorev.2021.03.010. Epub 2021 Mar 17.

Authors

P B Lukow¹, A Kiemes², M J Kempton³, F E Turkheimer⁴, P McGuire⁵, G Modinos⁶

Affiliations

¹ Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, SE5 8AF, London, UK. Electronic address: paulina.lukow@kcl.ac.uk.
² Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, SE5 8AF, London, UK. Electronic address: amanda.s.kiemes@kcl.ac.uk.
³ Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, SE5 8AF, London, UK. Electronic address: matthew.kempton@kcl.ac.uk.
⁴ Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, SE5 8AF, London, UK. Electronic address: federico.turkheimer@kcl.ac.uk.
⁵ Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, SE5 8AF, London, UK. Electronic address: philip.mcguire@kcl.ac.uk.
⁶ Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, SE5 8AF, London, UK; Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, SE5 8AF, London, UK; MRC Centre for Neurodevelopmental Disorders, King's College London, new hunt's House, Guy's Campus, SE1 1UL, London, UK. Electronic address: gemma.modinos@kcl.ac.uk.

Abstract

Aberrant emotion processing is a well-established component of psychotic disorders and is already present at the first episode of psychosis (FEP). However, the role of emotion processing abnormalities in the emergence of psychosis and the underlying neurobiology remain unclear. Here, we systematically reviewed functional magnetic resonance studies that used emotion processing task paradigms in FEP patients, and in people at clinical high-risk for psychosis (CHRp). Image-based meta-analyses with Seed-based d Mapping on available studies (n = 6) were also performed. Compared to controls, FEP patients showed decreased neural responses to emotion, particularly in the amygdala and anterior cingulate cortex. There were no significant differences between CHRp subjects and controls, but a high degree of heterogeneity was identified across studies. The role of altered emotion processing in the early phase of psychosis may be clarified through more homogenous experimental designs, particularly in the CHRp population.

Keywords: Clinical high-risk; Emotion; Functional magnetic resonance imaging; Psychosis; Seed-based d mapping.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

MeSH terms

Amygdala
Brain / diagnostic imaging
Emotions
Gyrus Cinguli
Humans
Magnetic Resonance Imaging*
Psychotic Disorders* / diagnostic imaging

Abstract

Publication types

MeSH terms

Grants and funding