Extracorporeal cardiopulmonary resuscitation for severe chloroquine intoxication in a child - a case report

Scand J Trauma Resusc Emerg Med. 2021 Mar 15;29(1):48. doi: 10.1186/s13049-021-00850-0.

Abstract

Background: Chloroquine use has increased worldwide recently in the setting of experimental treatment for the novel coronavirus disease (Covid-19). Nevertheless, in case of chloroquine intoxication, it can be life threatening, with cardiac arrest, due to its cardiac toxicity.

Case presentation: This case study reports on a 14-years-old girl who presented in cardiac arrest after an uncommon suicide attempt by ingesting 3 g of chloroquine. After 66 min of cardio-pulmonary resuscitation (CPR), extracorporeal cardiopulmonary resuscitation (ECPR) was initiated, allowing cardiac function to recover.

Conclusions: Chloroquine intoxication is a rare but serious condition due to its cardiac toxicity. Use of ECPR in this case of transient toxicity allowed a favorable evolution with little neurological impairment.

Keywords: Arrhythmia; Emergency medicine; Extracorporeal Life support; Intensive Care; Pediatrics; Resuscitation.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antimalarials / adverse effects
  • Antimalarials / therapeutic use
  • COVID-19 / epidemiology
  • COVID-19 Drug Treatment*
  • Cardiopulmonary Resuscitation / methods*
  • Chloroquine / adverse effects*
  • Chloroquine / therapeutic use
  • Extracorporeal Membrane Oxygenation / methods*
  • Female
  • Heart Arrest / chemically induced
  • Heart Arrest / therapy*
  • Humans
  • Pandemics
  • SARS-CoV-2
  • Severity of Illness Index

Substances

  • Antimalarials
  • Chloroquine