Tumor Necrosis Factor Alpha-Mediated Inflammation and Remodeling of the Extracellular Matrix Underlies Aortic Stiffening Induced by the Common Chemotherapeutic Agent Doxorubicin

Hypertension. 2021 May 5;77(5):1581-1590. doi: 10.1161/HYPERTENSIONAHA.120.16759. Epub 2021 Mar 15.

Abstract

[Figure: see text].

Keywords: anthracyclines; cardiovascular diseases; doxorubicin; elastic modulus; fibrosis.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology*
  • Aorta / drug effects*
  • Aorta / metabolism
  • Collagen / metabolism
  • Doxorubicin / pharmacology*
  • Elastin / metabolism
  • Extracellular Matrix / drug effects
  • Extracellular Matrix / metabolism*
  • Inflammation / metabolism*
  • Male
  • Mice
  • Pulse Wave Analysis
  • Tumor Necrosis Factor-alpha / metabolism*
  • Vascular Stiffness / drug effects*

Substances

  • Antineoplastic Agents
  • Tumor Necrosis Factor-alpha
  • Doxorubicin
  • Collagen
  • Elastin