As a worldwide challenge in the field of neurosurgery, there is no effective treatment method for pediatric skull defects repair in clinic. Currently clinical used cranioplasty materials couldn't undergo adjustment in response to skull growth and deformation. An ideal material for pediatric cranioplasty should fulfill the requirements of achieving complete closure, good osseointegration, biodegradability and conformability, sufficient cerebral protection and optimal aesthetic, and functional restoration of calvaria. Biomimetic mineralized collagen-based bone material is a kind of material that simulates the microstructural unit of natural bone on the nanometer scale. Because of its high osteogenic activity, it is widely used in repair of all kinds of bone defects. Recently, the biomimetic mineralized collagen-based bone materials have successfully been applied for cranial regeneration and repair with satisfactory results. This review mainly introduces the characteristics of the biomimetic mineralized collagen-based bone materials, the advantages for the repair of pediatric skull defects, and the related progresses.
儿童颅骨缺损修复是神经外科领域的世界性难题。临床上常见的颅骨修补材料无法满足儿童颅骨不断长大和变形的需求。理想的儿童颅骨修补材料应具有良好的诱导成骨能力，实现新骨再生和骨整合；具有匹配生长发育的可降解性能和顺应性，不限制正常骨骼生长；在修复过程中维持足够力学强度，保护颅内组织；易于塑形，满足美学需求。仿生矿化胶原骨材料是一种在微纳尺度上模拟天然骨最小结构单元的纳米复合材料，因其具有良好成骨活性而被成功应用于各种骨缺损修复。近年来，矿化胶原骨材料成功应用于颅骨再生修复，并取得了令人满意的修复效果。该综述重点介绍仿生矿化胶原骨材料的基本特点，及其用于儿童颅骨缺损再生修复的优势及相关研究进展。.
Keywords: Mineralized collagen; bone tissue engineering; pediatric cranioplasty; skull defect.