Durability of Viral Neutralization in Asymptomatic Coronavirus Disease 2019 for at Least 60 Days

J Infect Dis. 2021 May 28;223(10):1677-1680. doi: 10.1093/infdis/jiab140.

Abstract

A cohort consisting of asymptomatic healthcare workers donated temporal serum samples after infection with severe acute respiratory syndrome coronavirus 2. Analysis shows that all asymptomatic healthcare workers had neutralizing antibodies, that these antibodies persist for ≥60 days, and that anti-spike receptor-binding domain immunoglobulin G levels were correspondingly durable over the same time period.

Keywords: COVID-19; immunity; serologic test.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Antibodies, Neutralizing / blood*
  • Antibodies, Viral / blood*
  • Asymptomatic Diseases
  • COVID-19 / epidemiology
  • COVID-19 / immunology*
  • COVID-19 Nucleic Acid Testing
  • Cohort Studies
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Health Personnel
  • Humans
  • Male
  • Neutralization Tests
  • SARS-CoV-2 / immunology*
  • Surveys and Questionnaires
  • Time Factors
  • Virginia / epidemiology

Substances

  • Antibodies, Neutralizing
  • Antibodies, Viral