Volatile Anesthetics Regulate Anti-Cancer Relevant Signaling

Jiaqiang Wang; Chien-Shan Cheng; Yan Lu; Shen Sun; Shaoqiang Huang

doi:10.3389/fonc.2021.610514

Volatile Anesthetics Regulate Anti-Cancer Relevant Signaling

Front Oncol. 2021 Feb 26:11:610514. doi: 10.3389/fonc.2021.610514. eCollection 2021.

Authors

Jiaqiang Wang¹, Chien-Shan Cheng^{2

3}, Yan Lu⁴, Shen Sun¹, Shaoqiang Huang¹

Affiliations

¹ Department of Anesthesiology, The Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
² Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
³ Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
⁴ Department of Anesthesiology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.

Abstract

Volatile anesthetics are widely used inhalation anesthetics in clinical anesthesia. In recent years, the regulation of anti-cancer relevant signaling of volatile anesthetics has drawn the attention of investigators. However, their underlying mechanism remains unclear. This review summarizes the research progress on the regulation of anti-cancer relevant signaling of volatile anesthetics, including sevoflurane, desflurane, xenon, isoflurane, and halothane in vitro, in vivo, and clinical studies. The present review article aims to provide a general overview of regulation of anti-cancer relevant signaling and explore potential underlying molecular mechanisms of volatile anesthetics. It may promote promising insights of guiding clinical anesthesia procedure and instructing enhance recovery after surgery (ERAS) with latent benefits.

Keywords: anti-cancer; inhalation anesthesia; mechanism; volatile anesthesia; volatile anesthetics.

Publication types

Review