Prevalence and clinical correlates of insomnia symptoms and their association with quality of life in Chinese patients with HBV-related liver disease

Jing Zhao; Mei Liu; Gabor S Ungvari; Chee H Ng; Ines Hang Iao Chow; Ting Wang; Yu Chen; Zhongping Duan; Yu-Tao Xiang; Su-Jun Zheng

doi:10.7717/peerj.10956

Prevalence and clinical correlates of insomnia symptoms and their association with quality of life in Chinese patients with HBV-related liver disease

PeerJ. 2021 Mar 4:9:e10956. doi: 10.7717/peerj.10956. eCollection 2021.

Authors

Jing Zhao^#¹, Mei Liu^#¹, Gabor S Ungvari^{2

3}, Chee H Ng⁴, Ines Hang Iao Chow⁵, Ting Wang¹, Yu Chen¹, Zhongping Duan¹, Yu-Tao Xiang^{5

6}, Su-Jun Zheng¹

Affiliations

¹ Beijing YouAn Hospital, Capital Medical University, Beijing, China.
² University of Notre Dame Australia, Fremantle, Australia.
³ Division of Psychiatry, School of Medicine, University of Western Australia / Graylands Hospital, Perth, Australia.
⁴ Department of Psychiatry, The Melbourne Clinic and St Vincent's Hospital, University of Melbourne, Richmond, Victoria, Australia.
⁵ Center for Cognition and Brain Sciences, University of Macau, Macao SAR, China.
⁶ Institute of Advanced Studies in Humanities and Social Sciences, University of Macau, Macao SAR, China.

^# Contributed equally.

Abstract

Objective: This study aimed to describe the one-month prevalence of insomnia symptoms (insomnia hereafter) and the demographic and clinical correlates, and its association with quality of life (QOL) in Chinese patients with HBV-related liver disease.

Method: A total of 689 patients with HBV-related liver disease in Beijing, China formed the study sample. Three forms of insomnia including difficulty initiating sleep (DIS), difficulty maintaining sleep (DMS) and early morning awakening (EMA) were assessed using standardized questions. QOL was measured using the Medical Outcomes Study Short Form 12 (SF-12).

Results: The one-month prevalence of at least one type of insomnia was 69.5%, while DIS, DMS and EMA were 60.4%, 54.7% and 50.9%, respectively. Only 4.8% of patients suffering from insomnia received treatment. Multiple logistic regression analyses revealed that pre-existing medical conditions were positively associated with DIS and EMA; patients with more severe depressive symptoms were more likely to have DIS, DMS and EMA; local residents were less likely to have DIS; and those who were married and older were more likely to have DMS. Insomnia was not independently associated with QOL.

Conclusions: Insomnia is common in Chinese patients with HBV-related liver disease with a very low rate of treatment. Greater attention should be given to identify and treat insomnia in this patient population.

Keywords: China; HBV-related liver disease; Insomnia.

Grants and funding

This work was supported by Beijing Municipal Administration of Hospitals Clinical medicine Development of special funding support (XMLX201830, ZYLX202125). Grant of High technical personnel training item from Beijing Health System (2015-3-104); Scientific Research Common Program of Beijing Municipal Commission of Education (KM201610025021); National Science and Technology Key Project on “Major Infectious Diseases such as HIV/AIDS, Viral Hepatitis Prevention and Treatment” (2017ZX10202203-006, 2017ZX10302201-004). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.