Applications and challenges of low temperature plasma in pharmaceutical field

Lingge Gao; Xingmin Shi; Xili Wu

doi:10.1016/j.jpha.2020.05.001

Applications and challenges of low temperature plasma in pharmaceutical field

J Pharm Anal. 2021 Feb;11(1):28-36. doi: 10.1016/j.jpha.2020.05.001. Epub 2020 May 11.

Authors

Lingge Gao¹, Xingmin Shi¹, Xili Wu²

Affiliations

¹ School of Public Health, Medical Science Center, Xi'an Jiaotong University, Xi'an, 710061, China.
² Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, 710004, China.

Abstract

Low temperature plasma (LTP) technology has shown an outstanding application value in the pharmaceutical filed in recent ten years. This paper reviews the research advances in LTP, including its effects on enhancing or inhibiting drug activity, its combined use with drugs to treat cancers, its effects on the improvement of drug delivery system, its use in preparation of new inactivated virus vaccines, its use with mass spectrometry for rapid detection of drug quality, and the anti-tumor and sterilization effects of plasma-activated liquids. The paper also analyzes the challenges of LTP in the pharmaceutical filed, hoping to promote related research.

Keywords: Drug delivery system; Low temperature plasma; Nanodrug; Pharmacy; Plasma-activated liquids.

Publication types

Review