Structure and Function of Chromatin Remodelers

J Mol Biol. 2021 Jul 9;433(14):166929. doi: 10.1016/j.jmb.2021.166929. Epub 2021 Mar 10.

Abstract

Chromatin remodelers act to regulate multiple cellular processes, such as transcription and DNA repair, by controlling access to genomic DNA. Four families of chromatin remodelers have been identified in yeast, each with non-redundant roles within the cell. There has been a recent surge in structural models of chromatin remodelers in complex with their nucleosomal substrate. These structural studies provide new insight into the mechanism of action for individual chromatin remodelers. In this review, we summarize available data for the structure and mechanism of action of the four chromatin remodeling complex families.

Keywords: CHD; INO80; ISWI; SWI/SNF; chromatin remodeling.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Chromatin / chemistry
  • Chromatin / genetics*
  • Chromatin / metabolism
  • Chromatin Assembly and Disassembly*
  • Gene Expression Regulation
  • Humans
  • Nucleosomes / metabolism
  • Structure-Activity Relationship
  • Yeasts

Substances

  • Chromatin
  • Nucleosomes