Research advances of secretory proteins in malignant tumors

Na Zhang; Jiajie Hao; Yan Cai; Mingrong Wang

doi:10.21147/j.issn.1000-9604.2021.01.12

Research advances of secretory proteins in malignant tumors

Chin J Cancer Res. 2021 Feb 28;33(1):115-132. doi: 10.21147/j.issn.1000-9604.2021.01.12.

Authors

Na Zhang¹, Jiajie Hao¹, Yan Cai¹, Mingrong Wang¹

Affiliation

¹ State Key Laboratory of Molecular Oncology, Center for Cancer Precision Medicine, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

PMID: 33707934
PMCID: PMC7941687
DOI: 10.21147/j.issn.1000-9604.2021.01.12

Abstract

Secretory proteins in tumor tissues are important components of the tumor microenvironment. Secretory proteins act on tumor cells or stromal cells or mediate interactions between tumor cells and stromal cells, thereby affecting tumor progression and clinical treatment efficacy. In this paper, recent research advances in secretory proteins in malignant tumors are reviewed.

Keywords: Secretory protein; drug resistance; stromal cells; tumor microenvironment; tumor progression.