The efficacy of mesenchymal stem cells in regenerating structures associated with the temporomandibular joint: A systematic review

Arch Oral Biol. 2021 May:125:105104. doi: 10.1016/j.archoralbio.2021.105104. Epub 2021 Mar 6.

Abstract

Objectives: The objective of this systematic review is to evaluate the role of mesenchymal stem cells in the regenerative treatment of temporomandibular joint resorption.

Design: Search strategies were performed in the following databases: PubMed/MEDLINE, EMBASE, Cochrane Collaboration Library, and Web of Science. Two independent reviewers selected the included articles using a two-phase process based on the eligibility criteria. The reviewers independently collected the required information from the included articles. The methodological quality of the selected studies was assessed individually.

Result: In accordance with the inclusion and exclusion criteria, 703 studies were found and 8 articles were included. Thus, six studies using animal models and two human studies were included in this systematic review.

Conclusion: Based on the data of our systematic review, the use of mesenchymal stem cells is a promising method for the repair and regeneration of temporomandibular joint components.

Keywords: Mesenchymal stem cells; Temporomandibular joint disc; Temporomandibular joint disorders; Treatment.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Animals
  • Humans
  • Mesenchymal Stem Cells*
  • Regeneration
  • Temporomandibular Joint
  • Temporomandibular Joint Disorders* / therapy