Immune activation kickstarts the gut microbiota

Chun-Jun Guo

doi:10.1016/j.chom.2021.02.012

Immune activation kickstarts the gut microbiota

Cell Host Microbe. 2021 Mar 10;29(3):318-320. doi: 10.1016/j.chom.2021.02.012.

Author

Chun-Jun Guo¹

Affiliation

¹ Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Gastroenterology and Hepatology Division, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA. Electronic address: cj@guo-group.org.

PMID: 33705700
DOI: 10.1016/j.chom.2021.02.012

Abstract

The gut microbiota regulates intestinal immunity, but whether immune activation reciprocally alters gut commensals is unknown. In this issue of Cell Host & Microbe, Becattini et al. used a reductionist approach, incorporating gnotobiotic mouse models and multi-omics analyses, to address how gut commensals respond and adapt to acute immune activation.

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MeSH terms

Animals
Gastrointestinal Microbiome*
Germ-Free Life
Mice
Symbiosis