CircHIPK3: Key Player in Pathophysiology and Potential Diagnostic and Therapeutic Tool

Jiang Zhou; Baisheng Wang; Xin Bin; Changqing Xie; Bo Li; Ousheng Liu; Zhangui Tang

doi:10.3389/fmed.2021.615417

CircHIPK3: Key Player in Pathophysiology and Potential Diagnostic and Therapeutic Tool

Front Med (Lausanne). 2021 Feb 22:8:615417. doi: 10.3389/fmed.2021.615417. eCollection 2021.

Authors

Jiang Zhou¹, Baisheng Wang¹, Xin Bin¹, Changqing Xie¹, Bo Li¹, Ousheng Liu¹, Zhangui Tang¹

Affiliation

¹ Hunan Key Laboratory of Oral Health Research & Hunan 3D Printing Engineering Research Center of Oral Care & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, China.

Abstract

A large number of studies in China and other countries have confirmed that circularHIPK3 (circHIPK3) plays an important role in the pathophysiological processes of various diseases. Through the action of sponge miRNA (miR), circHIPK3 regulates cell proliferation, differentiation, and migration, and plays a key role in disease processes. By referring to a large number of research reports, this article explores the specific functional role of circHIPK3 in fibrotic diseases, cancer, and other diseases. This review aims to clarify the role of circHIPK3 in disease processes in order to aid further studies into the specific pathogenesis and clinical diagnosis of various diseases and provide new ideas for treatments.

Keywords: CircHIPK3; cancer; fibrosis; miRNA; pathophysiological; treatment.

Publication types

Review