Sepsis take-out: Inhibiting bacterial deliveries

Immunity. 2021 Mar 9;54(3):399-401. doi: 10.1016/j.immuni.2021.02.010.

Abstract

Sepsis remains a deadly disease with limited treatment options. In this issue of Immunity, Tang et al. propose that heparin provides protection during gram-negative sepsis by dampening harmful CASP11-dependent signaling through inhibition of HMGB1- and heparanase-mediated cytosolic delivery of LPS.

Publication types

  • Comment

MeSH terms

  • Gram-Negative Bacterial Infections*
  • HMGB1 Protein* / metabolism
  • Humans
  • Lipopolysaccharides
  • Sepsis*
  • Signal Transduction

Substances

  • HMGB1 Protein
  • Lipopolysaccharides