Abstract
Cytoplasmic vacuoles in precursors can be seen in a number of clinical settings, including copper deficiency, zinc toxicity, alcohol abuse, antibiotic treatment, myelodysplasia, and VEXAS syndrome. Gurnari et al asked how common VEXAS syndrome is in patients whose bone marrow aspirates show this distinctive feature, finding 2 diagnoses of VEXAS among 24 cases with vacuoles.
Publication types
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Clinical Trial Protocol
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Bone Marrow Cells* / enzymology
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Bone Marrow Cells* / pathology
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Child
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Erythroid Cells* / enzymology
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Erythroid Cells* / pathology
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Female
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Genes, X-Linked*
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Humans
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Male
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Middle Aged
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Mutation*
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Myeloid Cells* / enzymology
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Myeloid Cells* / pathology
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Myeloid Progenitor Cells* / enzymology
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Myeloid Progenitor Cells* / pathology
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Myeloproliferative Disorders* / enzymology
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Myeloproliferative Disorders* / genetics
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Myeloproliferative Disorders* / pathology
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Syndrome
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Ubiquitin-Activating Enzymes / genetics*
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Vacuoles* / enzymology
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Vacuoles* / genetics
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Vacuoles* / pathology
Substances
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UBA1 protein, human
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Ubiquitin-Activating Enzymes