Wireless and battery-free technologies for neuroengineering

Sang Min Won; Le Cai; Philipp Gutruf; John A Rogers

doi:10.1038/s41551-021-00683-3

Wireless and battery-free technologies for neuroengineering

Nat Biomed Eng. 2023 Apr;7(4):405-423. doi: 10.1038/s41551-021-00683-3. Epub 2021 Mar 8.

Authors

Sang Min Won^#¹, Le Cai^#², Philipp Gutruf^{3

4

5}, John A Rogers^{6

7

8

9

10

11

12

13

14}

Affiliations

¹ Department of Electrical and Computer Engineering, Sungkyunkwan University, Suwon, South Korea.
² Biomedical Engineering, College of Engineering, The University of Arizona, Tucson, AZ, USA.
³ Biomedical Engineering, College of Engineering, The University of Arizona, Tucson, AZ, USA. pgutruf@arizona.edu.
⁴ Bio5 Institute and Neuroscience GIDP, University of Arizona, Tucson, AZ, USA. pgutruf@arizona.edu.
⁵ Department of Electrical and Computer Engineering, University of Arizona, Tucson, AZ, USA. pgutruf@arizona.edu.
⁶ Department of Materials Science and Engineering, Northwestern University, Evanston, IL, USA. jrogers@northwestern.edu.
⁷ Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL, USA. jrogers@northwestern.edu.
⁸ Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA. jrogers@northwestern.edu.
⁹ Center for Advanced Molecular Imaging, Northwestern University, Evanston, IL, USA. jrogers@northwestern.edu.
¹⁰ Department of Mechanical Engineering, Northwestern University, Evanston, IL, USA. jrogers@northwestern.edu.
¹¹ Department of Chemistry, Northwestern University, Evanston, IL, USA. jrogers@northwestern.edu.
¹² Department of Neurological Surgery, Northwestern University, Evanston, IL, USA. jrogers@northwestern.edu.
¹³ Department of Electrical and Computer Engineering, Northwestern University, Evanston, IL, USA. jrogers@northwestern.edu.
¹⁴ Simpson Querrey Institute for BioNanotechnology, Northwestern University, Evanston, IL, USA. jrogers@northwestern.edu.

^# Contributed equally.

Abstract

Tethered and battery-powered devices that interface with neural tissues can restrict natural motions and prevent social interactions in animal models, thereby limiting the utility of these devices in behavioural neuroscience research. In this Review Article, we discuss recent progress in the development of miniaturized and ultralightweight devices as neuroengineering platforms that are wireless, battery-free and fully implantable, with capabilities that match or exceed those of wired or battery-powered alternatives. Such classes of advanced neural interfaces with optical, electrical or fluidic functionality can also combine recording and stimulation modalities for closed-loop applications in basic studies or in the practical treatment of abnormal physiological processes.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Electric Power Supplies
Models, Animal
Neurosciences*
Prostheses and Implants
Technology

Grants and funding

R01 NS112535/NS/NINDS NIH HHS/United States