Objective electroencephalography-based assessment for auditory rehabilitation of pediatric cochlear implant users

Guangjian Ni; Qi Zheng; Yidi Liu; Yawen Zhao; Tao Yue; Siyang Han; Haihong Liu; Dong Ming

doi:10.1016/j.heares.2021.108211

Objective electroencephalography-based assessment for auditory rehabilitation of pediatric cochlear implant users

Hear Res. 2021 May:404:108211. doi: 10.1016/j.heares.2021.108211. Epub 2021 Feb 18.

Authors

Guangjian Ni¹, Qi Zheng², Yidi Liu³, Yawen Zhao³, Tao Yue⁴, Siyang Han⁴, Haihong Liu⁵, Dong Ming⁶

Affiliations

¹ Department of Biomedical Engineering, College of Precision Instruments and Optoelectronics Engineering, Tianjin University, 300072, China; Academy of Medical Engineering and Translational Medicine, Tianjin University, 300072, China. Electronic address: niguangjian@tju.edu.cn.
² Department of Biomedical Engineering, College of Precision Instruments and Optoelectronics Engineering, Tianjin University, 300072, China.
³ Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, Department of Otolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University National Center for Children's Health, 100045, China.
⁴ Academy of Medical Engineering and Translational Medicine, Tianjin University, 300072, China.
⁵ Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, Department of Otolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University National Center for Children's Health, 100045, China. Electronic address: liuhaihong@bch.com.cn.
⁶ Department of Biomedical Engineering, College of Precision Instruments and Optoelectronics Engineering, Tianjin University, 300072, China; Academy of Medical Engineering and Translational Medicine, Tianjin University, 300072, China. Electronic address: richardming@tju.edu.cn.

PMID: 33684887
DOI: 10.1016/j.heares.2021.108211

Abstract

The cochlear implant (CI) has an effective habilitation modality for hearing-impaired children by promoting sound perception, vocalization, and language ability. However, the major challenge that remained was the lack of assessment standards for pediatric CI users, especially prelingually deaf children, to evaluate hearing rehabilitation effectiveness. In the present study, we conducted an oddball paradigm with stimuli varying in pure-tone, syllable, and tonal sounds. After implantation, we utilized cortical auditory evoked potential (CAEP) and mismatch negativity (MMN) to obtain time-domain analysis; meanwhile, the source localization was investigated to obtain spatial accuracy of the plasticity in the auditory cortex. P1 started to emerge at the third month after implantation, but its peak level was not significant until the sixth month. The temporal lobe was activated between the third and sixth months after implantation. The MMN waveform was basically normal approximately after 12 months. These results suggest that the auditory system goes through a critical period of rapid development between three and six months and enters a maturation period after 12 months. This work indicates that CAEPs are more suitable for assessing the early auditory system reconstruction, while MMN performs better in evaluating the advanced auditory function. Furthermore, source localization has proven to be an efficient tool in exploring auditory cortex plasticity, especially for pediatric CI users.

Keywords: Children; Cochlear implant; Cortical auditory evoked potential; Mismatch negativity; Source localization.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Auditory Cortex*
Child
Cochlear Implantation*
Cochlear Implants*
Deafness* / diagnosis
Deafness* / surgery
Electroencephalography
Evoked Potentials, Auditory
Humans
Speech Perception*