Ru complexes containing Cp, mPTA and natural purine bases (mPTA = methyl-N-1,3,5-triaza-7-phosphaadamantane): Evaluation of their antiproliferative activity, solubility and redox properties

J Inorg Biochem. 2021 May:218:111404. doi: 10.1016/j.jinorgbio.2021.111404. Epub 2021 Feb 23.

Abstract

Complexes [RuCp(Adeninate-κN9)(mPTA)2](Cl0.5)(CF3SO3)2.5·H2O (1·H2O), [RuCp(Guaninate-κN7)(mPTA)2](CF3SO3)2·H2O (2·H2O), [RuCp(Theophyllinate-κN7)(mPTA)2](CF3SO3)2·1.5H2O (3·1.5H2O) and [RuCp(Pur-κN)(mPTA)(PPh3)](CF3SO3) (4-6) (Pur = Adeninate, Guaninate, Teophyllinate; mPTA = N-methyl -1,3,5-triaza-7-phosphaadamantane) have been synthesized and characterized. Structure of complexes 1·H2O and 3·1.5H2O were determined by single-crystal X-ray diffraction. Solubility in water, Log P, electrochemical properties and antiproliferative activities of the complexes (against cisplatin-sensitive T2 and cisplatin-resistant SKOV3 cell lines) have been assessed and discussed.

Keywords: Antiproliferative activity; Natural purines; Ruthenium; Water-soluble complexes; mPTA.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cell Proliferation
  • Coordination Complexes / chemistry
  • Coordination Complexes / pharmacology*
  • Female
  • Humans
  • Ovarian Neoplasms / drug therapy*
  • Ovarian Neoplasms / pathology
  • Oxidation-Reduction
  • Purines / chemistry*
  • Quaternary Ammonium Compounds / chemistry*
  • Ruthenium / chemistry*
  • Solubility

Substances

  • Antineoplastic Agents
  • Coordination Complexes
  • Purines
  • Quaternary Ammonium Compounds
  • 4-(N-maleimido)benzyltrimethylammonium
  • Ruthenium