Ruthenium(ii)-catalyzed decarbonylative and decarboxylative coupling of isatoic anhydrides with salicylaldehydes: access to aryl 2-aminobenzoates

Org Biomol Chem. 2021 Mar 28;19(12):2725-2730. doi: 10.1039/d1ob00027f. Epub 2021 Mar 8.

Abstract

A ruthenium(ii)-catalyzed coupling reaction of isatoic anhydrides and salicylaldehydes has been developed for the synthesis of 2-aminobenzoates. This reaction proceeds through metal-catalyzed decarbonylation and decarboxylation to afford good yields of aryl 2-aminobenzoates.

Publication types

  • Research Support, Non-U.S. Gov't