The Roles of the LIM Domain Proteins in Drosophila Cardiac and Hematopoietic Morphogenesis

Meihua She; Min Tang; Tingting Jiang; Qun Zeng

doi:10.3389/fcvm.2021.616851

The Roles of the LIM Domain Proteins in Drosophila Cardiac and Hematopoietic Morphogenesis

Front Cardiovasc Med. 2021 Feb 11:8:616851. doi: 10.3389/fcvm.2021.616851. eCollection 2021.

Authors

Meihua She¹, Min Tang¹, Tingting Jiang², Qun Zeng¹

Affiliations

¹ Department of Biochemistry and Molecular Biology, College of Hengyang Medical, University of South China, Hengyang, China.
² Affiliated Nanhua Hospital, University of South China, Hengyang, China.

Abstract

Drosophila melanogaster has been used as a model organism for study on development and pathophysiology of the heart. LIM domain proteins act as adaptors or scaffolds to promote the assembly of multimeric protein complexes. We found a total of 75 proteins encoded by 36 genes have LIM domain in Drosophila melanogaster by the tools of SMART, FLY-FISH, and FlyExpress, and around 41.7% proteins with LIM domain locate in lymph glands, muscles system, and circulatory system. Furthermore, we summarized functions of different LIM domain proteins in the development and physiology of fly heart and hematopoietic systems. It would be attractive to determine whether it exists a probable "LIM code" for the cycle of different cell fates in cardiac and hematopoietic tissues. Next, we aspired to propose a new research direction that the LIM domain proteins may play an important role in fly cardiac and hematopoietic morphogenesis.

Keywords: Drosophila melanogaster; LIM domain; cardiac; development; hematopoietic.

Publication types

Review