IL-36 and IL-17A Cooperatively Induce a Psoriasis-Like Gene Expression Response in Human Keratinocytes

J Invest Dermatol. 2021 Aug;141(8):2086-2090. doi: 10.1016/j.jid.2021.01.019. Epub 2021 Mar 3.

Affiliations

¹ Laboratory of Investigative Dermatology, The Rockefeller University, New York, New York, USA.
² Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
³ Laboratory of Investigative Dermatology, The Rockefeller University, New York, New York, USA. Electronic address: jgk@rockefeller.edu.

PMID: 33675789
DOI: 10.1016/j.jid.2021.01.019

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Biopsy
Case-Control Studies
Datasets as Topic
Epidermis / immunology
Epidermis / pathology
Gene Expression Profiling
Gene Expression Regulation / immunology
Healthy Volunteers
Humans
Interleukin-1 / metabolism*
Interleukin-17 / metabolism*
Keratinocytes / immunology
Keratinocytes / metabolism
Keratinocytes / pathology
Oligonucleotide Array Sequence Analysis
Psoriasis / genetics
Psoriasis / immunology*
Psoriasis / pathology

Substances

IL17A protein, human
IL36G protein, human
Interleukin-1
Interleukin-17