Protease-antiprotease imbalance in patients with severe COVID-19

Clin Chem Lab Med. 2021 Mar 8;59(8):e330-e334. doi: 10.1515/cclm-2021-0137. Print 2021 Jul 27.
No abstract available

Keywords: ARDS; COVID-19; alpha-1 antitrypsin; elastase; matrix metalloprotease-12 (MMP-12).

Publication types

  • Letter

MeSH terms

  • Adult
  • Aged
  • Bronchoalveolar Lavage Fluid / chemistry
  • COVID-19 / pathology*
  • COVID-19 / virology
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Intensive Care Units
  • Leukocyte Elastase / blood*
  • Male
  • Matrix Metalloproteinase 12 / blood*
  • Middle Aged
  • SARS-CoV-2 / genetics
  • SARS-CoV-2 / isolation & purification
  • Severity of Illness Index
  • alpha 1-Antitrypsin / blood*

Substances

  • alpha 1-Antitrypsin
  • Leukocyte Elastase
  • Matrix Metalloproteinase 12